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August 16, 2026CureusOpen Access

An Uncommon Cause of Cystic Lung Disease

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Authors

KSKeegan SorensenAKAli KhreisatMPMark Parker

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Overview

Case report demonstrates pulmonary light chain deposition disease in a patient with Sjögren's syndrome, highlighting the utility of surgical biopsy and mass spectrometry.

Key Points

  • Describe a rare case of pulmonary light chain deposition disease presenting as cystic lung disease in a patient with Sjögren's syndrome.
  • Evaluated a 59-year-old female presenting with chronic cough, dyspnea, and progressive lung cysts and nodules using chest computed tomography and pulmonary function testing.
  • Performed diagnostic workup including serological testing, non-diagnostic transbronchial biopsy, thoracoscopic wedge resection with mass spectrometry, and bone marrow biopsy.
  • Pathology and mass spectrometry identified Congo red-negative eosinophilic deposits as kappa light chain deposition disease.
  • Bone marrow examination excluded hematologic malignancy, and immunosuppressive therapy with mycophenolate led to symptomatic improvement.

Cite This Study

Sorensen et al. (2026) studied this question.

synapsesocial.com/papers/6a817a91f2fb91fc834ae73ehttps://doi.org/10.7759/cureus.114563
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