Autonomy of Parathyroid Function After Renal Homotransplantation

Article1 November 1966Autonomy of Parathyroid Function After Renal HomotransplantationDUNCAN A. MCINTOSH, EMIL W. PETERSON, JOHN J. MCPHAUL JR.DUNCAN A. MCINTOSHSearch for more papers by this author, EMIL W. PETERSONSearch for more papers by this author, JOHN J. MCPHAUL JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-900 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSecondary hyperparathyroidism occurs commonly in chronically uremic patients (1-4). It has been felt to represent a physiologic adjustment to the hypocalcemia that results from impaired gastrointestinal absorption of calcium and renal phosphorus retention (5, 6). Although it appears to evolve as a compensating homeostatic mechanism, the hyperparathyroidism may lead to disabling symptomatology requiring vigorous medical or surgical therapy (5, 7-9). Indeed, the sequelae of the hyperparathyroid state may overshadow other symptoms of the uremia. It has been suggested that these hyperplastic parathyroid glands may lose their homeostatic role and that occasionally an autonomous state of hyperparathyroidism may develop (7, 10,...References1. CASTLEMANMALLORY BTB: Parathyroid hyperplasia in chronic renal insufficiency. Amer. J. Path. 13: 553, 1937. MedlineGoogle Scholar2. GILMOURMARTIN JRWJ: Weight of parathyroid glands. J. Path. Bact. 44: 431, 1937. CrossrefGoogle Scholar3. POLLACKSCHNEIDERFREUNDKARK VEAFGRM: Chronic renal disease with secondary hyperparathyroidism. Arch. Intern. Med. (Chicago) 103: 200, 1959. CrossrefGoogle Scholar4. NORDIN BE: Primary and secondary hyperparathyroidism. Advances Intern. Med. 9: 81, 1957. Google Scholar5. STANBURYLUMB SWGA: Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome. Medicine (Balt.) 41: 1, 1962. CrossrefMedlineGoogle Scholar6. KESSNEREPSTEIN DMFH: The effect of uremia on the gastrointestinal transport of calcium. Clin. Res. 11: 245, 1963. Google Scholar7. STANBURYLUMBNICHOLSON SWGAWF: Elective subtotal parathyroidectomy for renal hyperparathyroidism. Lancet 1: 793, 1960. CrossrefMedlineGoogle Scholar8. FINDLEYMOOREBRACKNEY TJDEL: Subtotal parathyroidectomy for renal hyperparathyroidism. Lancet 2: 1150, 1961. CrossrefGoogle Scholar9. STANBURYLUMB SWGA: The treatment of uremic renal osteodystrophy. Quart. J. Med. 28: 586, 1959. Google Scholar10. Case records of the Massachusetts General Hospital (Case 29—1963). New Eng. J. Med. 268: 943, 1963. CrossrefGoogle Scholar11. GOLDENCANARYKERWIN AJJDM: Concurrence of hyperplasia and neoplasia of the parathyroid glands. Amer. J. Med. 38, 526, 1965. CrossrefGoogle Scholar12. KYLECANARYMINTZDELEON LHJJDHA: Inhibitory effects of induced hypercalcemia on secretion of parathyroid hormone. J. Clin. Endocr. 22: 52, 1962. CrossrefGoogle Scholar13. MCINTOSHMCPHAULPETERSONHARVINSMITHCOOKHUMPHREYS DAJJEWJSJRFEJW: Homotransplantation of a cadaver neoplasm and a renal homograft. JAMA 192: 1171, 1965. CrossrefMedlineGoogle Scholar14. FALLSCARTERRECTORSELDIN WFNWFCDW: The mechanism of impaired phosphate reabsorption in chronic renal disease. Clin. Res. 14: 74, 1966. Google Scholar15. DAVISDENTWILLCOX DRCEA: Hyperparathyroidism and steatorrhea. Brit. Med. J. 2: 1133, 1956. CrossrefMedlineGoogle Scholar16. HUBBARDWENTWORTH RSJA: A case of metastatic calcification associated with chronic nephritis and hyperplasia of the parathyroids. Proc. Soc. Exp. Biol. Med. 18: 307, 1921. CrossrefGoogle Scholar17. HERBERTMILLERRICHARDSON FKHGGO: Chronic renal disease, secondary parathyroid hyperplasia, decalcification of bone, and metastatic calcification. J. Path. Bact. 53: 161, 1941. CrossrefGoogle Scholar18. MCPHAULMCINTOSHHAMMONDPARK JJDAWSOK: Autonomous secondary (renal) parathyroid hyperplasia. New Eng. J. Med. 271: 1342, 1964. CrossrefMedlineGoogle Scholar19. HERDMANMICHAELVERNIERKELLEYGOOD RCAFRLWDRA: Renal function and phosphorus excretion after human renal homotransplantation. Lancet 1: 121, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Departments of Medicine and Pathology, Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, San Antonio, Tex.Portions of this study were presented before the American Federation of Clinical Research, May 1, 1966, Atlantic City, N. J.Requests for reprints should be addressed to Major John J. McPhaul, Jr., MC, Chief, Renal Section, Wilford Hall USAF Hospital, Lackland Air Force Base, San Antonio, Tex. 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CHATTERJEE, M.B., G. F. COHEN, M.B., B.Ch., S. SAGAR, M.B.HYPERPARATHYROIDISM IN CHRONIC RENAL FAILURE ASSESSMENT OF AUTONOMY BY PLASMA-PARATHYROID-HORMONE RESPONSE TO ALTERATIONS IN CALCIUMHypercalcemia after renal transplantationRenal TransplantationTotal parathyroidectomy in the treatment of renal osteodystrophyKidney Transplantation: Patient Selection and ManagementSarcoidosis and primary hyperparathyroidismCALCIUM EXCRETION IN PATIENTS WITH RENAL ALLOGRAFTSIschemic Ulcerations of Skin and Necrosis of Muscle in Azotemic HyperparathyroidismJAMES A. RICHARDSON, M.D., F.A.C.P., GEORGE HERRON, M.D., RICHARD REITZ, M.D., ROBERT LAYZER, M.D.Physiologic studies in renal osteodystrophy treated by subtotal parathyroidectomyHAEMODIALYSIS AND TERTIARY HYPERPARATHYROIDISMHyperparathyroidism after Renal TransplantationSarcoidosis and hyperparathyroidismThe Renal Excretion of Nitrogen Containing MetabolitesResolution of Hyperparathyroidism, Renal Osteodystrophy and Metastatic Calcification after Renal HomotransplantationTransplantationCALCIFYING PANNICULITIS WITH FAT AND SKIN NECROSIS IN A CASE OF URÆMIA WITH AUTONOMOUS HYPERPARATHYROIDISMBone disease in uremiaMedical management of chronic renal failureEndocrine Aspects of SarcoidosisModerne Untersuchungsmethoden beim sekundären HyperparathyreoidismusRecent Progress in Osteomalacia and RicketsA. ROBERT ARNSTEIN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD M. FROST, M.D.22. Chirurgie der Epithelkörperchen26. Neue diagnostische, pathophysiologische und operativ-technische Probleme der Chirurgie der EpithelkörperchenPrimary Aldosteronism with Suppressed Plasma Renin Activity Due to Bilateral Nodular Adrenocortical HyperplasiaFRED H. KATZ, M.D. 1 November 1966Volume 65, Issue 5Page: 900-907KeywordsCalciumHomotransplantationHospital medicineHyperparathyroidismHypocalcemiaParathyroidPhosphorus Issue Published: 1 November 1966 PDF downloadLoading ...