Key result
Tc-99m MIBI gated SPECT and MUGA scan demonstrated equal efficiency in evaluating acute and chronic anthracycline-induced cardiotoxicity, with early LVEF drops predicting chronic toxicity.
Why the study?
Does Tc-99m MIBI gated SPECT compare equally to MUGA scan for the evaluation and forecast of anthracycline-induced cardiotoxicity in patients with malignant tumors?
Observational
Does Tc-99m MIBI gated SPECT compare equally to MUGA scan for the evaluation and forecast of anthracycline-induced cardiotoxicity in patients with malignant tumors?
MUGA and Gated SPECT are equally efficient for evaluating anthracycline-induced cardiotoxicity, and an early LVEF decrease of 10% or more can predict chronic cardiotoxicity.
To compare the possibility of using multiple-gated acquisition (MUGA) scan and Tc-99m MIBI gated SPECT for evaluation and forecast of anthracycline–induced cardiotoxicity. For the treatment of these patients we used doxorubicin in combination with various drugs. All patients were examined by MUGA or Gated SPECT before starting chemotherapy, at 1 hour after the first administration of doxorubicin and after the 4th course. The MUGA and Gated SPECT can be applied with equal efficiency for evaluation of acute and chronic anthracycline–induced cardiotoxicity in patients with malignant tumors. The decrease in LVEF (10% or more) in response to the first dose of doxorubicin can predict the development of chronic cardiotoxicity.
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Чернов et al. (2015) conducted an observational in Anthracycline-induced cardiotoxicity. Tc-99m MIBI gated SPECT vs. Multiple-gated acquisition (MUGA) scan was evaluated on Evaluation of acute and chronic anthracycline-induced cardiotoxicity. Tc-99m MIBI gated SPECT and MUGA scan demonstrated equal efficiency in evaluating acute and chronic anthracycline-induced cardiotoxicity, with early LVEF drops predicting chronic toxicity.
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