Key result
Acetylsalicylic acid is widely used for cardiovascular disease prevention, though issues like aspirin resistance and gender differences highlight the need for personalized antiplatelet therapy.
This review emphasizes the clinical challenges of aspirin resistance and gender-specific responses to acetylsalicylic acid, advocating for further development of individualized antiplatelet therapy.
Emphasizes aspirin resistance and gender differences as barriers to standard therapy; leaves open whether personalized antiplatelet strategies improve outcomes.
According to the statistical forecasting the cardiovascular mortality will be 25 million cases per year in 2020. Therefore, the search for effective ways to treat and prevent cardiovascular diseases is the primary objective of the current medicine. It has been shown that one of the main groups of drugs that positively affect the duration and quality of life, are antiplatelet agents. Acetylsalicylic acid is an antiplatelet agent that is most widely used for both the primary and secondary prevention of cardiovascular diseases. This article discusses the problems of aspirin resistance, possible ways to improve the efficacy and safety of acetylsalicylic acid therapy, the impact of gender on its effectiveness, and others. There is the need for further development of methods for determining the mechanisms of formation of sensitivity and the rational prescription and correction of the therapy with acetylsalicylic acid.
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Зупанец et al. (2016) conducted a review in Cardiovascular diseases. Acetylsalicylic acid was evaluated. Acetylsalicylic acid is widely used for cardiovascular disease prevention, though issues like aspirin resistance and gender differences highlight the need for personalized antiplatelet therapy.
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