Key result
The sarcoplasmic/endoplasmic reticulum in cardiac myocytes may physically and functionally integrate protein synthesis with contractile calcium handling.
This review highlights the potential physical and functional integration of protein synthesis and contractile calcium handling in the sarcoplasmic/endoplasmic reticulum of cardiac myocytes.
Does not yet alter clinical management; leaves open experimental validation of SR/ER integration in myocyte remodeling.
Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac contractile calcium handling is well established, its roles in protein synthesis, folding, and quality control in cardiac myocytes are not as clear. This review explores evidence suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may be physically and functionally integrated.
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Christopher C. Glembotski (2012) studied this question. The sarcoplasmic/endoplasmic reticulum in cardiac myocytes may physically and functionally integrate protein synthesis with contractile calcium handling.
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