This review provides insights into the evolution of cardiac design and function in vertebrates by examining the structural basis of sarcoplasmic reticulum function across species.
The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence suggests differences in SR function across species may have an underlying structural basis. Here, we discuss how SR recruitment relates to the structural organization of the cardiomyocyte to provide new insight into the evolution of cardiac design and function in vertebrates.
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Shiels et al. (2014) studied this question.
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