Why the study?
Post-operative vitamin D supplementation improves CRC survival outcomes in randomised trials, but the feasibility, safety, and efficacy of pre- and perioperative vitamin D in patients undergoing CRC surgery remained to be tested.
Does perioperative 3200IU oral cholecalciferol improve 25OHD levels and reduce CRP in patients undergoing colorectal cancer resection?
Population
122 patients undergoing CRC surgery
Comparison
3200IU oral cholecalciferol per day perioperatively vs untreated CRC controls
Design
Feasibility study
Key result
High-dose perioperative vitamin D supplementation significantly reduced the rate of early postoperative vitamin D insufficiency to 14% compared to 56% in untreated controls.
Authors
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May support perioperative vitamin D repletion in colorectal resection; leaves open randomized confirmation of CRP and outcome effects.
Cohort (n=122)
No
Does perioperative 3200IU oral cholecalciferol improve 25OHD levels and reduce CRP in patients undergoing colorectal cancer resection?
Absolute Event Rate: 14% vs 56%
p-value: p=0.003
High-dose perioperative vitamin D supplementation is feasible, increases 25OHD levels, and reduces early postoperative CRP in patients undergoing colorectal cancer resection.
Vaughan-Shaw et al. (2022) conducted a cohort in Colorectal cancer (n=122). Vitamin D3 (Cholecalciferol) vs. Untreated controls was evaluated on Early postoperative vitamin D insufficiency (25OHD < 50nmol/l) (p=0.003). High-dose perioperative vitamin D supplementation significantly reduced the rate of early postoperative vitamin D insufficiency to 14% compared to 56% in untreated controls.