Key result
Preoperative 25-OH vitamin D levels show no independent association with infectious complications.
Why the study?
Determining modifiable risk factors for postoperative complications is significant in colorectal surgery patients due to their association with worse long-term outcomes.
Do preoperative 25-OH vitamin D levels predict postoperative complications in patients undergoing colorectal cancer surgery?
Cohort (n=104)
No
Do preoperative 25-OH vitamin D levels predict postoperative complications in patients undergoing colorectal cancer surgery?
Odds Ratio: 0.92 (95% CI 0.83–1.02)
p-value: p=0.13
Lower preoperative vitamin D levels are associated with increased infectious complications following colorectal cancer surgery.
No independent association after adjustment; leaves open whether vitamin D optimization trials are warranted in colorectal cancer surgery.
BACKGROUND: Determining the modifiable risk factors for postoperative complications is particularly significant in patients undergoing colorectal surgery since those are associated with worse long-term outcomes. METHODS: Consecutive newly diagnosed 104 colorectal cancer patients were prospectively included in this single-center observational study. Preoperative serum 25-OH vitamin D levels were measured and analyzed for infectious and postoperative complications. RESULTS: Serum 25-OH vitamin D levels were found to be < 20 ng/ml in 74 patients (71.2%) and ≥ 20 ng/ml in 30 patients (28.8%); and the mean serum 25-OH vitamin D level was 15.95 (± 9.08) ng/ml. In patients with surgical site infection and infectious complications, 25-OH vitamin D levels were significantly lower than patients without complications (p = 0.036 and p = 0.026). However, no significant difference was demonstrated in 25-OH vitamin D levels according to overall postoperative complications. CONCLUSIONS: Our results suggest that vitamin D levels might be a potential risk factor for infectious complications in patients undergoing colorectal cancer surgery.
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Balcı et al. (2021) conducted a cohort in Colorectal cancer (n=104). Preoperative 25-OH vitamin D levels vs. Patients without complications was evaluated on Infectious complications (OR 0.92, 95% CI 0.83-1.02, p=0.13). Preoperative 25-OH vitamin D levels were significantly lower in patients with infectious complications on univariate analysis (p=0.026), though this association was not significant on multivariate analysis (OR 0.92).
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