Key result
Preoperative vitamin D concentration was not associated with a 30-day composite of cardiovascular events after noncardiac surgery (OR 0.93; 95% CI 0.85-1.01; P=0.095 per 10 nmol/l increase).
Why the study?
Low 25-hydroxyvitamin D is associated with cardiovascular, renal, and infectious risks, but whether vitamin D deficiency contributes to postoperative complications after noncardiac surgery remains unclear.
Is preoperative vitamin D concentration associated with postoperative cardiovascular events in patients aged ≥45 years undergoing noncardiac surgery?
Population
3,851 patients aged at least 45 yr undergoing noncardiac surgery with at least an overnight hospitalization
Comparison
Preoperative 25-hydroxyvitamin D concentrations
Design
Cohort biobank substudy
Follow-up
30 days
Authors
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Vitamin D assessment should not guide perioperative cardiovascular risk stratification; leaves open associations with infection and renal outcomes.
Cohort (n=3,851)
Is preoperative vitamin D concentration associated with postoperative cardiovascular events in patients aged ≥45 years undergoing noncardiac surgery?
Effect estimate: OR 0.93 (95% CI 0.85, 1.01)
p-value: p=0.095
Preoperative vitamin D concentration is not associated with 30-day postoperative cardiovascular events after noncardiac surgery, though it may be associated with infectious complications and kidney function.
Turan et al. (2019) conducted a cohort in Noncardiac surgery (n=3,851). Preoperative 25-hydroxyvitamin D concentration was evaluated on Composite of cardiovascular events (death, myocardial injury, nonfatal cardiac arrest, stroke, congestive heart failure) within 30 postoperative days (OR 0.93, 95% CI 0.85, 1.01, p=0.095). Preoperative vitamin D concentration was not associated with a 30-day composite of cardiovascular events after noncardiac surgery (OR 0.93; 95% CI 0.85-1.01; P=0.095 per 10 nmol/l increase).
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