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January 12, 2013European Heart JournalOpen Access

Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery

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Why the study?

Does pre-operative vitamin D status predict the risk of MACCE in cardiac surgical patients?

Population

4,418 cardiac surgical patients in Central Europe

Comparison

Pre-operative 25-hydroxyvitamin D (25D) levels vs Pre-operative 25(OH)D levels of 75-100 nmol/L

Design

Cohort

Follow-up

12 months

Authors

AZArmin ZittermannJKJoachim KühnJDJ Dreier

Discussion

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Overview

Should not yet guide pre-operative vitamin D management in cardiac surgery; hypothesis-generating for U-shaped MACCE risk.

Structured PICO

Does pre-operative vitamin D status predict the risk of MACCE in cardiac surgical patients?

P
Population
4,418 cardiac surgical patients in Central Europe
I
Intervention
Pre-operative 25-hydroxyvitamin D (25(OH)D) levels (deficient <30 nmol/L, insufficient 30-49.9 nmol/L, or high >100 nmol/L)
C
Comparator
Pre-operative 25(OH)D levels of 75-100 nmol/L
O
Outcome
Major cardiac and cerebrovascular events (MACCE)composite

Pre-operative vitamin D deficiency and excess are both independently associated with an increased risk of major adverse cardiac and cerebrovascular events following cardiac surgery, demonstrating a U-shaped risk relationship.

Cite This Study

Zittermann et al. (2013) studied this question.

synapsesocial.com/papers/6a87de4b6e1dca10b7bb6176https://doi.org/10.1093/eurheartj/ehs468
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review2021 · 1 citations
  2. 2Low Vitamin D Concentration Is Not Associated with Increased Mortality and Morbidity after Cardiac Surgery2013 · 18 citations
  3. 3Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery2019 · 15 citations
  4. 4The Association of Serum Vitamin D Concentration with Serious Complications After Noncardiac Surgery2014 · 26 citations
  5. 5Lower Levels of Vitamin D Are Associated with Higher Vasoactive–Inotropic Scores in Major Cardiac Surgery2024 · 1 citations