Key result
Congenital heart disease surgery caused a 40% decline in 25-hydroxyvitamin D (58.0 to 34.2 nM); lower postoperative levels were associated with catecholamine requirement (26.5 vs 38.2 nM, P=0.007).
Why the study?
Does anesthesia and surgery for congenital heart disease reduce serum 25-hydroxyvitamin D levels in children?
Cohort (n=58)
No
Does anesthesia and surgery for congenital heart disease reduce serum 25-hydroxyvitamin D levels in children?
Absolute Event Rate: 34.2% vs 58%
Surgery for congenital heart disease, particularly the initiation of cardiopulmonary bypass, causes a significant acute decline in vitamin D levels, which is associated with increased postoperative support requirements.
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Postoperative vitamin D monitoring should not yet guide care in pediatric CHD surgery; hypothesis-generating for supplementation trials.
McNally et al. (2013) conducted a cohort in Congenital heart disease (n=58). Congenital heart disease surgery vs. Preoperative baseline was evaluated on Serum 25-hydroxyvitamin D (25OHD) level. Congenital heart disease surgery caused a 40% decline in 25-hydroxyvitamin D (58.0 to 34.2 nM); lower postoperative levels were associated with catecholamine requirement (26.5 vs 38.2 nM, P=0.007).
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