Key result
Pre-operative daily high-dose cholecalciferol supplementation significantly reduced the risk of post-operative vitamin D deficiency compared to usual care in children with congenital heart disease (RR 0.31).
Why the study?
Most children undergoing cardiac surgery develop post-operative vitamin D deficiency, potentially worsening outcomes, making feasibility and dosing evaluation necessary before a large phase III trial.
Does high-dose cholecalciferol prevent post-operative vitamin D deficiency in children with congenital heart disease undergoing cardiopulmonary bypass?
RCT (n=46)
Double-blind
1:1 in permuted blocks of four, stratified by age, expected time to surgery, and feeding status
No
Does high-dose cholecalciferol prevent post-operative vitamin D deficiency in children with congenital heart disease undergoing cardiopulmonary bypass?
Relative Risk: 0.31 (95% CI 0.11–0.87)
Absolute Event Rate: 43% vs 84%
Pre-operative high-dose cholecalciferol safely and effectively reduces the incidence of post-operative vitamin D deficiency in children undergoing cardiopulmonary bypass for congenital heart disease.
No takes yet. Share an insight, caveat, or question.
Supports pre-operative high-dose cholecalciferol to prevent post-operative vitamin D deficiency in pediatric congenital heart surgery; extends RCT evidence on targeted perioperative supplementation.
McNally et al. (2020) conducted an RCT in Congenital heart disease requiring surgical correction with cardiopulmonary bypass (n=46). Cholecalciferol (Vitamin D3) vs. Usual care (400 IU/day for < 1 year, 600 IU/day for > 1 year) was evaluated on Immediate post-operative serum 25-hydroxyvitamin D concentration under 50 nmol/L (RR 0.31, 95% CI 0.11-0.87). Pre-operative daily high-dose cholecalciferol supplementation significantly reduced the risk of post-operative vitamin D deficiency compared to usual care in children with congenital heart disease (RR 0.31).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: