Key result
Cardiac surgery significantly reduced 25-(OH)-VitD levels 24 hours postoperatively (SMD 0.84), and lower postoperative levels were associated with severe adverse events.
Why the study?
Studies assessing 25-hydroxyvitamin D levels and the relationship between vitamin D deficiency and adverse outcomes after cardiac surgery had reported inconsistent results.
Does 25-(OH)-VitD deficiency predict adverse clinical outcomes in patients undergoing cardiac surgery?
Comparison
25-(OH)-VitD levels before vs after surgery, and deficiency vs sufficiency
Design
Systematic review and meta-analysis
Authors
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May support postoperative vitamin D monitoring for risk stratification after cardiac surgery; confirms prognostic association in meta-analysis.
Meta-Analysis (n=1,785)
Does 25-(OH)-VitD deficiency predict adverse clinical outcomes in patients undergoing cardiac surgery?
Standardized Mean Difference: 0.84 (95% CI 0.47–1.21)
p-value: p=0.000
Cardiac surgery leads to a significant decrease in 25-(OH)-VitD levels, and postoperative deficiency is associated with worse clinical outcomes and higher vasoactive-inotropic scores.
Zhang et al. (2021) conducted a meta-analysis in Cardiac surgery (n=1,785). Cardiac surgery vs. Preoperative baseline was evaluated on 25-(OH)-VitD level 24 hours after surgery (SMD 0.84, 95% CI 0.47-1.21, p=0.000). Cardiac surgery significantly reduced 25-(OH)-VitD levels 24 hours postoperatively (SMD 0.84), and lower postoperative levels were associated with severe adverse events.
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