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The renal concentrating and diluting mechanism was examined in dogs with unilateral chronic hydronephrosis and compared to the contralateral normal side. Urine concentrating ability and concentrating capacity were markedly impaired in the chronically hydronephrotic kidney. However, as previously reported, fractional free water clearance over a large range of distal delivery was identical in both kidneys. Significant reductions in papillary and medullary nonurea solute concentration were present in the hydronephrotic kidneys as compared to controls during both hydropenia and hydration.
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Eknoyan et al. (1970) studied this question.
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