Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1999Biochemistry

Characterizing the Response of Calcium Signal Transducers to Generated Calcium Transients

View Full Paper
Ask AI
Bookmark
Share

Population

Calcium indicators, Ca2+-binding proteins, and Ca2+-dependent enzymes

Design

Preclinical

Authors

JDJonathan P. DavisThe Ohio State University Wexner Medical CenterSTSvetlana B. TikunovaThe Ohio State UniversityMWMichael P. WalshUniversity College Dublin

Discussion

Loading...

Member takes

Implication

No immediate clinical implications; extends kinetic models of troponin C and SERCA but leaves open in vivo translation.

Structured PICO

P
Population
Calcium indicators, Ca2+-binding proteins (troponin C, calmodulin), and Ca2+-dependent enzymes (myosin light chain kinase, sarcoplasmic reticulum Ca2+/ATPase)
I
Intervention
Exposure to artificial Ca2+ transients (ACTs) of varying duration (0.1-50 ms half-widths) and amplitude
O
Outcome
Transient binding of Ca2+, complex formation, and/or enzyme activationsurrogate

Artificial calcium transients allow visualization of how calcium-exchange rates of calcium-binding proteins dictate their conformational changes and interactions, enabling predictions of their responses to natural cellular calcium transients.

Cite This Study

Davis et al. (1999) studied this question.

synapsesocial.com/papers/6a8181b6cda74e78d11ae2fbhttps://doi.org/10.1021/bi982495z
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of Ca2+ transients and tension by intracellular EGTA in intact frog muscle fibers1997 · 37 citations
  2. 2Transient state kinetic studies of sarcoplasmic reticulum adenosine triphosphatase.1975 · 217 citations
  3. 3Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2+1993 · 166 citations
  4. 4Parvalbumin relaxes frog skeletal muscle when sarcoplasmic reticulum Ca(2+)-ATPase is inhibited1996 · 222 citations
  5. 5Reversal of the cross‐bridge force‐generating transition by photogeneration of phosphate in rabbit psoas muscle fibres.1992 · 383 citations