Why the study?
What are the current methods and challenges in monitoring oral anticoagulant therapy?
What are the current methods and challenges in monitoring oral anticoagulant therapy?
While LC-MS/MS is the gold standard for DOAC measurement when necessary, the lack of simple, rapid laboratory tests for emergent situations remains an unresolved clinical challenge.
Oral anticoagulants antivitamin-K (ОАС - AVК) are highly effective drugs that prevent the development of venous thrombosis, stroke in atrial fibrillation. Routine monitoring is not recommended for DOAC. If measurements are necessary LC-MS/MS is the gold standard. The classical coagulation assays, PT-INR and aPTT, have no or very limited utility. The absence of the ability of simple laboratory tests in emergent or urgent surgery or procedures still remains unresolved.
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Antović et al. (2018) conducted a review in Venous thrombosis and stroke in atrial fibrillation. Oral anticoagulant monitoring was evaluated.
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