What question did this study set out to answer?

To evaluate evidence across human, animal, and in-vitro studies regarding how macronutrients and micronutrients influence cancer initiation, progression, and clinical management.

February 16, 2018European Journal of Cancer Prevention

The rationale for a role for diet and nutrition in the prevention and treatment of cancer

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Authors

JLJean LoganUppsala University MBMegan W. BourassaNew York Academy of Sciences

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Implication

Narrative review demonstrates strong links between nutrition and tumor progression in preclinical and human populations, highlighting the therapeutic value of plant-based dietary interventions.

Key Points

To evaluate evidence across human, animal, and in-vitro studies regarding how macronutrients and micronutrients influence cancer initiation, progression, and clinical management.
Assessed findings from epidemiological research, including the China Project, investigating correlations between animal product intake and disease incidence.
Synthesized data from in-vitro and animal models examining food restriction, animal protein intake, and plant-derived phytochemicals.
Examined underlying biological mechanisms, including nutrient-sensing pathways, epigenetic alterations, and gut microbiome-derived metabolites.
Animal protein and animal product consumption correlate with cancer promotion, whereas food restriction suppresses cancer progression across both human and animal models.
Phytochemicals from whole plant foods counteract oxidative stress, arrest cell cycles, induce apoptosis, block angiogenesis, and inhibit cyclooxygenase-2 related to metastasis.
Dietary components modulate tumor biology through insulin signaling, mammalian target of rapamycin (mTOR) activation, epigenetic gene regulation, and gut microbial metabolites.

Cite This Study

Logan et al. (2018) studied this question.

synapsesocial.com/papers/6a8183bdb06901c4fb22e320 https://doi.org/10.1097/cej.0000000000000427

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Implication

Narrative review demonstrates strong links between nutrition and tumor progression in preclinical and human populations, highlighting the therapeutic value of plant-based dietary interventions.

The rationale for a role for diet and nutrition in the prevention and treatment of cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

The rationale for a role for diet and nutrition in the prevention and treatment of cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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