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This review highlights the 125-year history of acetylsalicylic acid, its mechanisms, clinical evidence, resistance, and pleiotropic effects.
An experience of acetylsalicylic acid (ASA) clinical use since its synthesis in 1887 is highlighted. ASA modes of action and its position among the modern antiplatelet agents are considered. The evidence based clinical data on ASA treatment and the problem of antiplatelet therapy resistance are discussed. ASA interaction with other drugs and ASA pleiotropic effects are reviewed
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Бокарев et al. (2011) studied this question.
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