New Cyclopeptide and γ-Butyrolactone Derivatives from an Endophytic Strain of Cophinforma mamane

High Resolution Image Download MS PowerPoint Slide From an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana, a previously undescribed γ-butyrolactone compound ( 2 ) and three new cyclopentapeptides ( 3 - 5 ) have been isolated from the same strain, along with the known (4 R) -striatisporolide A ( 1 ). Their structures were elucidated through extensive spectral analysis and DP4+ calculations. The two γ-butyrolactone derivatives ( 1, 2 ) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC 50 = 13.33 and 4.43 μM, respectively), while only compound 2 displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity against Enterococcus faecalis (MIC = 64 μg/mL).