Acute Isoniazid Intoxication — Management by Peritoneal Dialysis

IN spite of the widespread use of isonicotinic acid hydrazide since 1952 few accidental poisonings are reported. Four cases of acute isoniazid intoxication have been reported in the English literature. The first was by Katz and Carver1 in which a nineteen-month-old child ingested 900 mg. of isoniazid and was successfully treated by exchange transfusion. Soon thereafter Livingston, Petersen and Peck2 described a 10-kg., twenty-six-month-old patient who was estimated to have ingested 1500 mg. of isoniazid. These workers chose to treat their patient symptomatically, with barbiturates and intravenous infusions. The last report was that of Hyatt,3 who successfully treated 2 children, . . .