Key result
Carbohydrate drinks did not significantly affect the hemodynamic status compared to water up to 4 hours after drinking, as measured by the collapsibility index of the inferior vena cava (p=0.867).
Why the study?
The study was conducted to investigate the effects of administering water versus high-carbohydrate-containing fluids on hemodynamic status in volunteers using inferior vena cava collapsibility index measurement.
Does high-carbohydrate fluid compared to water affect hemodynamic status (IVCCI) and gastric volume in healthy volunteers?
RCT (n=20)
Double-blind
Computer-generated random numbers in a 1:1 ratio
No
Does high-carbohydrate fluid compared to water affect hemodynamic status (IVCCI) and gastric volume in healthy volunteers?
Preoperative carbohydrate drinks do not affect hemodynamic status compared to water but may delay gastric emptying at 1 hour in healthy volunteers.
Carbohydrate drinks show hemodynamic equivalence to water preoperatively; confirms safety regarding volume status while leaving gastric emptying effects open in healthy volunteers.
BACKGROUND AND OBJECTIVE: Inferior vena cava (IVC) examination has been reported as a noninvasive method for evaluating the hemodynamic state. We conducted this crossover pilot study to investigate the effects of the administration of water and high-carbohydrate-containing fluids on the hemodynamic status of volunteers through collapsibility index of IVC (IVCCI) measurement. METHODS: Twenty volunteers were randomly assigned to a water or high-carbohydrate group according to computer-generated random numbers in a 1:1 ratio. In the water group, volunteers received water (5 mL/kg), and in the high-carbohydrate group, patients received carbohydrate drinks (5 mL/kg). Respiratory variations in the IVC diameter, gastric volume, and blood pressure and heart rates in erect and supine positions were measured at admission (T1), 1 h (T2), 2 h (T3), 3 h (T4), and 4 h (T5). RESULTS: When considering participants with an IVCCI of more than 42%, there were no significant differences between the water and carbohydrate drink groups at each time point (all p > 0.05). At T2, more participants had an empty stomach in water group than in carbohydrate drink group (p < 0.001). At T3, 30% of the participants could not empty their stomachs in carbohydrate drink group. However, with regard to the number of volunteers with empty stomach at T3, there was no significant difference between water and carbohydrate drink group. Repeated measures data analysis demonstrated that IVCCI showed no significant differences over time (p = 0.063 for T1-T5). There were no differences between water and carbohydrate drinks (p = 0.867). CONCLUSION: Our results suggested that neither water nor carbohydrate drinking affected the hemodynamic status through IVCCI measurement over time, up to 4 h after drinking. Furthermore, carbohydrate drinking might delay gastric emptying at 1 h, but not 2 h after drinking, in comparison with water.
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Zhao et al. (2022) conducted an RCT in Healthy volunteers (n=20). Carbohydrate drinks vs. Water was evaluated on Collapsibility index of inferior vena cava (IVCCI) (p=0.867). Carbohydrate drinks did not significantly affect the hemodynamic status compared to water up to 4 hours after drinking, as measured by the collapsibility index of the inferior vena cava (p=0.867).
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