July 1, 1977Clinical Pharmacology & Therapeutics
Response optimization of drug dosage: Antiarrhythmie studies with tocainide
Why the study?
Does pharmacokinetic modeling of tocainide plasma concentrations improve the assessment of antiarrhythmic response in individual patients?
Population
15 patients receiving multiple oral doses of a new antiarrhythmic, tocainide
Design
Cohort
Authors
Discussion
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Implication
Marked variability in tocainide response may warrant individualized dosing; leaves open whether PK modeling improves outcomes in trials.
Structured PICO
Does pharmacokinetic modeling of tocainide plasma concentrations improve the assessment of antiarrhythmic response in individual patients?
P
Population
15 patients receiving multiple oral doses of a new antiarrhythmic, tocainide
I
Intervention
Tocainide (multiple oral doses) with pharmacokinetic/pharmacodynamic modeling for dosage optimization
O
Outcome
Graded antiarrhythmic response and simultaneously measured plasma drug concentrationssurrogate
Pharmacokinetic modeling of tocainide demonstrates marked inter-individual variability in antiarrhythmic response for identical doses, highlighting the need for individualized dosing.
Cite This Study
Meffin et al. (1977) studied this question.