Key result
Poor immune status assessed by CD4+ nadir in HIV patients with acute coronary syndrome was not associated with significant differences in major adverse cardiac and cerebrovascular events at 1 year.
Why the study?
Data suggest immune status and CD4+ cell count may contribute to cardiovascular complications in HIV-infected patients, prompting analysis of the relationship between CD4+ nadir and clinical outcomes.
Does poor immune status (assessed by CD4+ nadir) increase major adverse cardiac and cerebrovascular events in HIV-infected patients with acute coronary syndrome?
Cohort (n=50)
Does poor immune status (assessed by CD4+ nadir) increase major adverse cardiac and cerebrovascular events in HIV-infected patients with acute coronary syndrome?
In HIV patients with acute coronary syndrome, a lower CD4+ nadir is associated with more complex coronary lesions and higher bleeding risk, but not with a significant increase in 1-year major adverse cardiovascular events.
People living with HIV infection are at high risk for cardiovascular events due to inflammation and atherosclerosis. Also, some antiretroviral therapies may contribute to the risk of cardiovascular complications. Immune status is highly dependent on the level of lymphocyte T helper CD4+. There are data suggesting that immune status and CD4+ cell count may be involved in the development of cardiovascular complications in these patients. Our study is longitudinal and retrospective and included a total number of 50 patients with HIV infection associated with acute coronary syndrome, divided into two subgroups based on the nadir of CD4+ cells. This study analyzes the relationship between the immune status of HIV patients, assessed by the nadir of the CD4+ T-cell count, and the outcome of these patients. Also, secondary endpoints were the assessment of the magnitude of coronary lesions and of thrombotic and bleeding risk assessed by specific scores. Clinical and biological parameters and also the extension and complexity of coronary lesions were assessed. Although patients with poor immune status had more complex coronary lesions and increased operative risk and bleeding risk at one year, this was not associated with significant differences in major adverse cardiac and cerebrovascular events at the 30-day and 1-year outcomes.
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Bajdechi et al. (2023) conducted a cohort in HIV infection and acute coronary syndrome (n=50). Poor immune status (low CD4+ nadir) vs. Higher CD4+ nadir was evaluated on Major adverse cardiac and cerebrovascular events at 30 days and 1 year. Poor immune status assessed by CD4+ nadir in HIV patients with acute coronary syndrome was not associated with significant differences in major adverse cardiac and cerebrovascular events at 1 year.
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