HLA plays a critical role in hematopoietic cell transplantation, but a full understanding of this role is constantly in flux because of changing technologies and burgeoning amounts of clinical transplantation results. Today the clinician considering unrelated donor transplantation must also consider stem cell source: an adult donor or an umbilical cord blood unit (CBU). In the context of cord blood, the task is further complicated by the strong interaction of cell dose.
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Hurley et al. (2006) studied this question.
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