Key result
Supportive care with fenofibrate cuts triglycerides ~52% and resolves acute pancreatitis without recurrence.
Why the study?
Does supportive care (fasting, intravenous fluids, and oral lipid-lowering therapy without plasmapheresis or heparin) resolve acute hypertriglyceridemia-induced pancreatitis and lower triglyceride levels?
Case Report (n=1)
No
Does supportive care (fasting, intravenous fluids, and oral lipid-lowering therapy without plasmapheresis or heparin) resolve acute hypertriglyceridemia-induced pancreatitis and lower triglyceride levels?
Answers are grounded in this paper and cite their sources.
This case report illustrates that hypertriglyceridemia-induced pancreatitis can present with normal serum amylase levels and may be successfully managed with conservative supportive care and oral fibrates without requiring invasive plasmapheresis or heparin infusion.
Hypertriglyceridemia is a rare cause of pancreatitis. In treatment pancreatic rest, lifestyle changes, medications (fibrates, n-3 polyunsaturated fatty acids, and nicotinic acid) are essential. Many experimental treatment modalities have been reported as insulin and heparin infusion and plasmapheresis. In this study we present the hypertriglyceridemia-induced pancreatitis treated with supportive care.
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Uysal et al. (2014) conducted a case report in Hypertriglyceridemia-induced pancreatitis (chylomicronemia syndrome) (n=1). Supportive care (nil per mouth, intravenous fluid therapy, and oral medical therapy including fenofibrate and continuation of insulin glargine) was evaluated on Clinical resolution of pancreatitis and reduction in triglyceride levels at hospital discharge (day 9).
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