Key result
Transcranial Doppler assessment demonstrated a relationship between cerebral large artery disease and the severity of cerebral small vessel disease, though not embolic in nature.
Why the study?
The study aimed to investigate the pathogenesis of cerebral small vessel disease, specifically the involvement of large artery disease, and evaluate transcranial Doppler for assessing disease severity and identifying high-risk individuals.
Can transcranial Doppler assessment evaluate the severity and pathogenesis of cerebral small vessel disease in patients without cardioembolic risk?
Cross-Sectional (n=50)
Can transcranial Doppler assessment evaluate the severity and pathogenesis of cerebral small vessel disease in patients without cardioembolic risk?
Transcranial Doppler, specifically the Breath-Holding Index, may be a useful noninvasive tool for predicting the occurrence and assessing the severity of cerebral small vessel disease, particularly in hypertensive patients.
May support TCD as noninvasive marker in hypertensives; hypothesis-generating and requires prospective validation before practice change.
BackgroundCerebral small vessel disease (SVD) refers to any pathology in all vascular structures (small arteries, arterioles, capillaries, venules, and small veins). Transcranial Doppler is a bedside, inexpensive, noninvasive technique that can assess intracerebral circulation in real time and can be used for continuous monitoring.Aim of the workOur study tried to detect the pathogenesis of cerebral SVD, especially the implication of the cerebral large artery disease. Moreover, it assessed the ability of transcranial Doppler in evaluating the severity of cerebral SVD and people who are at risk. Patients with cardioembolic risk were excluded.Patients and methodsA cross-sectional study was conducted including 50 patients recruited from El-Sahel Teaching Hospitals, either inpatient or outpatient clinic departments.ResultsWe proved a relation between cerebral large artery disease and severity of cerebral SVD but not embolic in nature.ConclusionThere is a relationship between cerebral large artery disease and severity of cerebral SVD, but we cannot hold microemboli as a pathogenesis of cerebral SVD. In addition, cerebral SVD affects cerebral vasomotor reactivity especially in hypertensive patients, so we can use Breath-Holding Index (BHI) for prediction of occurrence of cerebral SVD in high-risk people, especially hypertensive.
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Shaaban et al. (2019) conducted a cross-sectional in Cerebral small vessel disease (n=50). Transcranial Doppler assessment was evaluated on Relationship between cerebral large artery disease and severity of cerebral small vessel disease. Transcranial Doppler assessment demonstrated a relationship between cerebral large artery disease and the severity of cerebral small vessel disease, though not embolic in nature.
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