The normal stages of bone modeling and remodeling occur following the implantation of carbon plugs. 2. Glassy carbon bars aged in vivo for five months did not undergo statistically significant weakening. 3. Glassy carbon does undergo static fatigue when aged in a simulated biological environment. However, the conditions necessary to cause this failure are extreme. 4. Minimal tissue response was seen to the presence of the carbon.
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Kenner et al. (1975) studied this question.
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