Experimental analysis of ceramic‐tissue interactions. A morphologic, fluoroescenseoptic, and radiographic study on dense alumina oxide ceramic in various animals

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Two types of dense Al 2 O 3 ceramics (99.6% purity, 96% purity) were tested in the following fields of interest. Wear resistibility using a pin and disk method under distilled water and human synovial fluid. Both types showed minimal initial corpuscular wear. Biocompatibility of ceramic wear particles in mice and rats after injection by different ways. The crystal material is permanently deposited in macrophages, after transport via lymphpatic and blood vessels also in the RES without chronic inflammatory and progressive fibrotic response. Under moderate stress conditions ceramic plates are fixed firmly by new bone formation within 2–3 months according to tetracycline label studies of bone growth in rats. A new ceramic total hip prosthesis with two different socket designs for cement free fixation in bone is proposed and used in sheep experiments. The results of a 4 month experiment is presented showing firm fixation of the prosthesis under full stress conditions.