Population
Newborn dogs during the first 15 days of extrauterine life
Comparison
Stimulation of renin release via peritoneal… vs Adult dogs and unstimulated state
Design
Preclinical
Follow-up
15 days
Authors
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Indicates mature renin secretion in newborn dogs; extends developmental physiology but leaves open human translation.
The formation and secretion of renin is well developed in the kidneys of newborn dogs despite the absence of demonstrable juxtaglomerular cell granules.
Granger et al. (1971) studied this question.
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