Key result
Pretreatment with 10 mg/kg naringin significantly alleviated doxorubicin-induced oxidative stress in mice bone marrow cells by raising antioxidant status, including glutathione and catalase levels.
Why the study?
Does naringin reduce doxorubicin-induced oxidative stress in mice bone marrow cells?
Does naringin reduce doxorubicin-induced oxidative stress in mice bone marrow cells?
Naringin alleviates doxorubicin-induced oxidative stress in mice bone marrow by raising antioxidant status.
Doxorubicin an anthracylcine group of antibiotics is under frequent clinical use to treat numerous neoplastic disorders and it kills cancer cells by inducing different reactive oxygen species that increase oxidative stress in the neoplastic cells.
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Jagetia et al. (2017) studied Doxorubicin-induced oxidative stress (n=240). Naringin vs. Doxorubicin alone was evaluated on Glutathione (GSH) concentration at 4 hours post-treatment (10 mg/kg doxorubicin) (p=<0.05). Pretreatment with 10 mg/kg naringin significantly alleviated doxorubicin-induced oxidative stress in mice bone marrow cells by raising antioxidant status, including glutathione and catalase levels.
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