Key result
Overweight or obesity significantly increased the risk of major adverse cardiovascular events in acute coronary syndrome compared to normal body mass index (OR 1.20; 95% CI 1.12-1.29; p<0.001).
Why the study?
The relationship between body mass index and major adverse cardiovascular events in patients with acute coronary syndrome required systematic examination to guide body weight management.
Does being overweight or obese increase the risk of major adverse cardiovascular events in patients with acute coronary syndrome?
Meta-Analysis (n=58,992)
Does being overweight or obese increase the risk of major adverse cardiovascular events in patients with acute coronary syndrome?
Being overweight or obese is associated with a 20% increased risk of major adverse cardiovascular events in patients with acute coronary syndrome, highlighting the importance of weight management.
Background: In this meta-analysis, we aimed to systematically examine the relationship between body mass index and major adverse cardiovascular events in acute coronary syndrome patients and to provide theoretical guidance for body weight management in these patients. Methods: A comprehensive analysis of applicable research published between 2008 and 2021 was conducted using the PubMed, Cochrane, Web of Science, Wanfang, and CNKI databases. Extracted odds ratios from the randomized-controlled studies were pooled using fixed-effects meta-analysis. Publication bias was addressed through evaluation methods such as funnel plot or sensitivity analysis. Results: Ten studies with a total of 58,992 individuals were included. The consequences of this meta-analysis confirmed that, compared to normal body mass index, patients with acute coronary syndrome significantly increased the risk of major adverse cardiovascular events (odds ratio= 1.20; 95% confidence interval: 1.12-1.29, p<0.001). Conclusion: Patients with acute coronary syndrome being overweight or obese significantly increased the risk of major adverse cardiovascular events compared to those with normal body mass index. The results suggest that patients may focus on weight management to reduce the risk of major adverse cardiovascular events in acute coronary syndrome.
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Wei et al. (2024) conducted a meta-analysis in acute coronary syndrome (n=58,992). Overweight or obesity vs. Normal body mass index was evaluated on major adverse cardiovascular events (OR 1.20, 95% CI 1.12-1.29, p=<0.001). Overweight or obesity significantly increased the risk of major adverse cardiovascular events in acute coronary syndrome compared to normal body mass index (OR 1.20; 95% CI 1.12-1.29; p<0.001).
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