Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 2025International Medical Case Reports JournalOpen Access

Intravenous insulin infusion with dextrose and potassium successfully reduced triglyceride levels from 1509 mg/dL to 81 mg/dL and resolved acute pancreatitis in a resource-limited setting.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Hypertriglyceridemia-induced acute pancreatitis is an uncommon cause of acute pancreatitis that can lead to significant morbidity if not promptly identified and managed.

Population

45-year-old male with poorly controlled T2DM and hyperlipidemia presenting with HTG-AP

Design

Case report

Key result

Intravenous insulin infusion with dextrose and potassium successfully reduced triglyceride levels from 1509 mg/dL to 81 mg/dL and resolved acute pancreatitis in a resource-limited setting.

Authors

HAHussein Mahdi AhmedMOMohamed Hassan OsmanSHShafie Abdulkadir Hassan

Discussion

Loading...

Member takes

Overview

May support IV insulin as alternative in resource-limited hypertriglyceridemia pancreatitis; hypothesis-generating case report requiring prospective validation.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
A 45-year-old male with poorly controlled type 2 diabetes mellitus and hyperlipidemia who presented with hypertriglyceridemia-induced acute pancreatitis and was followed for approximately 3.5 months.
I
Intervention
Intravenous infusion of short-acting insulin (Actrapid) with dextrose and potassium replacement, analgesics (paracetamol), intravenous fluids (crystalloids), and thromboprophylaxis (enoxaparin).
O
Outcome
Reduction of triglyceride levels and clinical recovery from acute pancreatitissurrogate

Intravenous insulin infusion is a practical and effective alternative for rapidly reducing triglyceride levels in hypertriglyceridemia-induced acute pancreatitis when plasmapheresis is unavailable in resource-limited settings.

Limitations

  • Absence of xanthomas can contribute to a delay in the diagnosis of HTG-AP.
  • Elevated triglyceride levels can interfere with colorimetric testing of amylase, potentially leading to deceptively normal results.
  • Plasmapheresis, a standard therapy for severe HTG-AP, may not be available in resource-limited settings.

Cite This Study

Ahmed et al. (2025) conducted a case report in Hypertriglyceridemia-Induced Acute Pancreatitis (n=1). Intravenous insulin, dextrose, and potassium infusions was evaluated on Reduction of triglyceride levels and clinical recovery. Intravenous insulin infusion with dextrose and potassium successfully reduced triglyceride levels from 1509 mg/dL to 81 mg/dL and resolved acute pancreatitis in a resource-limited setting.

synapsesocial.com/papers/6a819fff5feb15765cbf61abhttps://doi.org/10.2147/imcrj.s516349
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertriglyceridaemia-induced pancreatitis2023 · 2 citations
  2. 2O-29 SEVERE HYPERTRIGLYCERIDAEMIA-INDUCED PANCREATITIS WITH NON-CARDIOGENIC PULMONARY OEDEMA IN A YOUNG INDIAN MAN WITH NEWLY DIAGNOSED DIABETES: A RARE AND CHALLENGING PRESENTATION2026
  3. 3Hypertriglyceridemia-Induced Acute Pancreatitis2017 · 8 citations
  4. 4Hypertriglyceridemia-Induced Pancreatitis With Rapid Response to Insulin Therapy2020 · 5 citations
  5. 5Acute Pancreatitis Secondary to Severe Hypertriglyceridemia: Management of Severe Hypertriglyceridemia in Emergency Setting2017 · 23 citations