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The synthesis and antimicrobial activities of a series of α-substituted phenylacetamido-cephalosporanic acids are reported. Among the prepared cephalosporanic acids, α-chloro-phenylacetamido-cephalosporamic acid (2) and α-(2, 6-dichlorophenoxy)phenylacetamido-cepha-losporanic acid (17) showed a high effect against both E. coli and Staphylococcus aureus.
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Takano et al. (1967) studied this question.
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