April 27, 2004CirculationOpen Access

Attenuation of Oxidative Stress and Remodeling by Cardiac Inhibitor of Metalloproteinase Protein Transfer

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Why the study?

Does CIMP administration attenuate oxidative stress and MMP-mediated cardiac dilatation in a mouse model of volume overload-induced heart failure?

Structured PICO

Does CIMP administration attenuate oxidative stress and MMP-mediated cardiac dilatation in a mouse model of volume overload-induced heart failure?

Population

C57BL/J6 mice with Arteriovenous fistula (AVF) or sham, n=24 (4 groups of n=6)

Intervention

Cardiac inhibitor of metalloproteinase (CIMP) administered by protein transfer into peritoneal cavity by minipump for 4 weeks

Comparator

No CIMP administration (sham or AVF alone)

Outcome

Oxidative stress (NADPH oxidase activity), MMP activity, and cardiac dilatation/contractile dysfunctionsurrogate

In a mouse model of volume overload-induced heart failure, CIMP protein transfer attenuated oxidative stress, MMP activity, and left ventricular dilatation.

Discussion

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Implication

Hypothesis-generating for CIMP in volume-overload HF; leaves open clinical translation.

Cite This Study

Cox et al. (2004) studied this question.

synapsesocial.com/papers/6a81aa00d976967348bf6010 https://doi.org/10.1161/01.cir.0000127429.53391.78

Topics

Heart failure HFrEF treatment

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Attenuation of Oxidative Stress and Remodeling by Cardiac Inhibitor of Metalloproteinase Protein Transfer

Structured PICO

Discussion

Implication

Cite This Study

Topics

Attenuation of Oxidative Stress and Remodeling by Cardiac Inhibitor of Metalloproteinase Protein Transfer

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider