Key result
Cytomegalovirus infection was associated with a 22% increased relative risk of future cardiovascular disease (RR 1.22; 95% CI 1.07-1.38; P=0.002).
Why the study?
Does cytomegalovirus infection increase the risk of cardiovascular disease in community-based populations?
Meta-Analysis (n=34,564)
Does cytomegalovirus infection increase the risk of cardiovascular disease in community-based populations?
Relative Risk: 1.22 (95% CI 1.07–1.38)
p-value: p=0.002
Cytomegalovirus infection is associated with a 22% increased relative risk of future cardiovascular disease, suggesting a potential infectious contributor to CVD risk.
Identifies a potential infectious contributor to cardiovascular risk that should not yet change practice; leaves open.
Background Several studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease ( CVD ); however, the results are inconsistent. We aimed to provide a systematic review and meta‐analysis of community‐based prospective studies assessing the association between cytomegalovirus infection and relative risk of CVD . Methods and Results We searched Medline and EMBASE to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of CVD . The search yielded 10 articles including a total of 34 564 participants and 4789 CVD patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95% CI : 1.07–1.38, P =0.002) increased relative risk of future CVD . We estimated that 13.4% of CVD incidence could be attributable to cytomegalovirus infection. Conclusions In conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of CVD .
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Wang et al. (2017) conducted a meta-analysis in Cardiovascular Disease (n=34,564). Cytomegalovirus infection vs. No cytomegalovirus infection was evaluated on Future cardiovascular disease (RR 1.22, 95% CI 1.07-1.38, p=0.002). Cytomegalovirus infection was associated with a 22% increased relative risk of future cardiovascular disease (RR 1.22; 95% CI 1.07-1.38; P=0.002).
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