Why the study?
Does allopurinol alter mortality and hospitalisations in patients with chronic heart failure?
Does allopurinol alter mortality and hospitalisations in patients with chronic heart failure?
In patients with chronic heart failure, long-term high-dose allopurinol (≥300 mg/day) is associated with lower mortality compared to long-term low-dose allopurinol.
No takes yet. Share an insight, caveat, or question.
Should not yet change allopurinol dosing in chronic HF; leaves open whether high doses reduce mortality in RCTs.
Allan D. Struthers (2002) studied this question.
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