Key result
Aspirin resistance was present in 7.4% of ischemic stroke patients and 4% of healthy controls, and was significantly associated with stroke recurrence (p=0.004).
Why the study?
To evaluate the prevalence of aspirin resistance in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention.
What is the prevalence of aspirin resistance in ischemic stroke patients compared to healthy controls, and is it associated with stroke recurrence?
Case-Control (n=450)
What is the prevalence of aspirin resistance in ischemic stroke patients compared to healthy controls, and is it associated with stroke recurrence?
Aspirin resistance is present in a minority of Colombian ischemic stroke patients but is significantly associated with an increased risk of stroke recurrence.
Answers are grounded in this paper and cite their sources.
Aspirin resistance may flag higher recurrence risk but should not change practice; leaves open need for prospective validation.
Objective. To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. Materials and Methods. Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. Results. Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>p</a:mi> <a:mo>=</a:mo> <a:mn>0.004</a:mn> </a:math> ). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. Conclusion. Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.
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Naranjo et al. (2021) conducted a case-control in Ischemic stroke (n=450). Previous ischemic stroke vs. Healthy controls was evaluated on Aspirin resistance. Aspirin resistance was present in 7.4% of ischemic stroke patients and 4% of healthy controls, and was significantly associated with stroke recurrence (p=0.004).
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