Key result
Aspirin resistance was detected in 15.3% of patients with ischemic stroke, with no significant relationship found between resistance and stroke-related clinical or laboratory parameters.
Why the study?
What is the frequency of aspirin resistance in acute ischemic stroke patients treated with aspirin?
Observational (n=163)
What is the frequency of aspirin resistance in acute ischemic stroke patients treated with aspirin?
Aspirin resistance is present in approximately 15% of acute ischemic stroke patients, though it does not appear to correlate with standard clinical or laboratory parameters.
Answers are grounded in this paper and cite their sources.
Aspirin resistance affects 15% of acute ischemic stroke patients without identifiable correlates; leaves open its prognostic value or testing utility.
Objective: Aspirin is the basic agent of antithrombotic treatment in ischemic cerebrovascular disease (CVD).Patients who do not respond to the treatment are described as aspirin-resistant.Recent studies have reported an incidence of aspirin resistance among CVD patients of between 3% and 85%.The aim of this study was to determine the frequency of aspirin resistance in CVD patients and evaluate any relationship with demographic characteristics, risk factors, or stroke subtypes.Methods: A total of 163 (106 male, 57 female) acute ischemic stroke patients from a 6-month period treated with aspirin (100 mg, 300 mg daily) were evaluated.Aspirin resistance was measured using a Multiplate platelet analyzer (Roche Diagnostics, Risch-Rotkreuz, Switzerland).Potential correlations between aspirin resistance and stroke subtypes, age, sex, weight, height, hypertension, diabetes mellitus, history of CVD, tobacco use, alcohol use, hyperlipidemia, and fasting blood glucose level were analyzed.Results: Aspirin resistance was determined in 16 male patients and 9 female patients in the group: a total of 25 (15.3%) of 163 patients.There was no statistically significant relationship between aspirin resistance and stroke-related clinical and laboratory parameters.Conclusion: Additional, large, prospective, randomized studies are needed to clarify which patients with ischemic stroke should be tested and how to treat patients with resistance.
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Anıl Bulut (2018) conducted an observational in Ischemic stroke (n=163). Aspirin (100-300 mg/day) was evaluated on Frequency of aspirin resistance. Aspirin resistance was detected in 15.3% of patients with ischemic stroke, with no significant relationship found between resistance and stroke-related clinical or laboratory parameters.
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