Key result
Echovirus 12 strains isolated from healthy children in China shared 80.8-80.9% nucleotide identity with the prototype strain and exhibited intertypic recombination in non-structural regions.
Cross-Sectional (n=8)
No
This study provides the first complete genome sequences of echovirus 12 in China, revealing high genetic diversity and intertypic recombination in non-structural regions.
May inform enterovirus surveillance in Asia; leaves open pathogenicity of recombinant strains.
Human echovirus 12 (E-12) belongs to the enterovirus B species. To date, only one full-length genome sequence of E-12 (prototype strain Travis) is available in the GenBank database. This study determined the complete sequence of three E-12 strains, which were isolated from the stools of three healthy children in Yunnan, China, in 2013. We revealed that the three Yunnan E-12 strains had only 80.8-80.9% nucleotide identity and 96.4-96.8% amino acid identity with the Travis strain based on pairwise comparisons of the complete genome nucleotide and amino acid sequences. The three Yunnan strains shared 99.7% nucleotide identity and 99.1-99.5% amino acid similarity. Phylogenetic and similarity plot analyses showed that intertypic recombination occurred in the non-structural regions of the three Yunnan E-12 strains. This is the first report of the complete genome sequence of E-12 in China and it enriches the complete genome sequences of E-12 in the GenBank database.
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Liu et al. (2018) conducted a cross-sectional in Healthy (asymptomatic) (n=8). Echovirus 12 was evaluated on Complete genome sequence and phylogenetic analysis. Echovirus 12 strains isolated from healthy children in China shared 80.8-80.9% nucleotide identity with the prototype strain and exhibited intertypic recombination in non-structural regions.
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