Key result
Cerebrospinal fluid pleocytosis was present in 67.5% of children with enteroviral meningitis and was associated with increased CSF protein and pressure, but not with age or peripheral WBC count.
Observational (n=80)
Yes
In children with enteroviral meningitis, CSF pleocytosis is associated with increased CSF protein and pressure but not with age or peripheral inflammatory markers.
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CSF pleocytosis links to higher protein and pressure in pediatric enteroviral meningitis; leaves open prognostic value or management implications.
Objective: Enteroviruses are major causes of aseptic meningitis in children. This study aimed to describe the clinical manifestations of enteroviral meningitis according to the presence of cerebrospinal fluid (CSF) pleocytosis, and to investigate the factors influencing the CSF pleocytosis in children with this condition. Methods: Eighty children with enteroviral meningitis treated at Soonchunhyang University Hospitals in Seoul and Bucheon between July 2012 and August 2013 were enrolled. The patients were diagnosed by reverse transcription-polymerase chain reaction (RT-PCR), and the clinical variables were compared according to the presence of CSF pleocytosis. Results: Of the 80 patients, 54 (67.5%) and 26 (32.5%) patients had and did not have CSF pleocytosis, respectively. Forty-eight (60%) patients were male, and the median age was 63 months (range, 2 to 192 months). Seventy-six (95%), 67 (83.7%), 51 (63.7), and 2 (2.5%) patients presented with fever, headache, vomiting, and seizure, respectively. Increased CSF protein and pressure were associated with CSF pleocytosis. However, age, peripheral white blood cell count, C-reactive protein, CSF glucose, CSF/serum glucose ratio, and onset-puncture time interval were not associated with the presence of CSF pleocytosis.
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Ahn et al. (2015) conducted an observational in Enteroviral meningitis (n=80). Cerebrospinal fluid (CSF) pleocytosis vs. Absence of CSF pleocytosis was evaluated on Clinical manifestations and factors influencing CSF pleocytosis. Cerebrospinal fluid pleocytosis was present in 67.5% of children with enteroviral meningitis and was associated with increased CSF protein and pressure, but not with age or peripheral WBC count.
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