Key result
Younger age (adjusted OR 0.981; 95% CI 0.973-0.989), lower peripheral WBC count, and shorter interval to lumbar puncture were significantly associated with the absence of CSF pleocytosis.
Why the study?
What is the proportion of enteroviral meningitis without CSF pleocytosis in infants and children, and what factors are associated with its absence?
Population
390 infants and children with enteroviral meningitis diagnosed by CSF reverse transcription-PCR testing
Design
Cohort
Authors
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May warrant enterovirus PCR in young infants despite absent pleocytosis; leaves open prospective validation of diagnostic algorithms.
Observational (n=390)
Yes
What is the proportion of enteroviral meningitis without CSF pleocytosis in infants and children, and what factors are associated with its absence?
Odds Ratio: 0.981 (95% CI 0.973–0.989)
p-value: p=<0.001
A significant proportion of young infants with enteroviral meningitis do not exhibit CSF pleocytosis, highlighting the importance of CSF enterovirus PCR testing for accurate diagnosis in this population.
Yun et al. (2012) conducted an observational in Enteroviral meningitis (n=390). Younger age, lower peripheral white blood cell count, and shorter interval to lumbar puncture was evaluated on Proportion of enteroviral meningitis without CSF pleocytosis (adjusted OR 0.981, 95% CI 0.973 to 0.989, p=<0.001). Younger age (adjusted OR 0.981; 95% CI 0.973-0.989), lower peripheral WBC count, and shorter interval to lumbar puncture were significantly associated with the absence of CSF pleocytosis.
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