March 1, 1994Pacing and Clinical Electrophysiology
Insights Into the Pathogenesis of Sudden Cardiac Death From Analysis of Circadian Fluctuations of Potential Triggering Factors
Population
Patients prone to sudden cardiac death, particularly those with compromised left ventricular function
Design
Review
Authors
Discussion
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Implication
May inform chronotherapy timing in high-risk patients; leaves open prospective trials of autonomic modulation for SCD prevention.
Structured PICO
P
Population
Patients prone to sudden cardiac death, particularly those with compromised left ventricular function
I
Intervention
Therapeutic measures aiming at a reduction in sympathetic input to the heart
O
Outcome
Sudden cardiac death and ventricular fibrillation
Circadian fluctuations in autonomic tone, particularly increased sympathetic activity in the morning, play a key role in triggering sudden cardiac death, highlighting the importance of therapies that reduce sympathetic input.
Cite This Study
Hohnloser et al. (1994) studied this question.