Key result
Crushed 90-mg and 180-mg ticagrelor tablets prepared for oral or naso-gastric tube administration delivered a mean dose recovery of ≥97% of the original tablet with no degradation after 2 hours.
Why the study?
Does crushing ticagrelor tablets for oral or naso-gastric tube administration maintain adequate drug recovery and stability?
Population
Ex vivo model using 90-mg and 180-mg ticagrelor tablets and polyvinylchloride, polyurethane, and silicone…
Design
Preclinical
Authors
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May support crushed ticagrelor for tube feeding in dysphagic patients; leaves open human PK confirmation before practice change.
Does crushing ticagrelor tablets for oral or naso-gastric tube administration maintain adequate drug recovery and stability?
Crushing ticagrelor tablets for oral or naso-gastric tube administration yields ≥97% drug recovery and remains stable for up to 2 hours, providing a practical administration method for patients with swallowing difficulties.
Crean et al. (2013) studied Acute Coronary Syndromes. Crushed ticagrelor tablets vs. Intact tablet dose (reference standard) was evaluated on Mean percentage of ticagrelor recovered from the samples compared with the intact tablet dose. Crushed 90-mg and 180-mg ticagrelor tablets prepared for oral or naso-gastric tube administration delivered a mean dose recovery of ≥97% of the original tablet with no degradation after 2 hours.
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