What question did this study set out to answer?

To assess the relationship between peripheral oxidative stress markers and systemic inflammation in patients with stable relapsing-remitting multiple sclerosis exhibiting low disability.

November 1, 2019Journal of Clinical MedicineOpen Access

Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis

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Authors

RPRodica PădureanuUniversity of Medicine and Pharmacy of Craiova CACarmen Valeria AlbuUniversity of Medicine and Pharmacy of Craiova RMRadu Răzvan MititeluUniversity of Medicine and Pharmacy of Craiova

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Implication

Case-control study reveals elevated neutrophil-lymphocyte ratio correlates with decreased antioxidant capacity in multiple sclerosis, suggesting oxidative stress promotes early neuronal damage.

Key Points

To assess the relationship between peripheral oxidative stress markers and systemic inflammation in patients with stable relapsing-remitting multiple sclerosis exhibiting low disability.
Enrolled 31 participants into two cohorts: 16 relapsing-remitting multiple sclerosis patients with low disability (mean age 38.9 ± 7.08 years, median EDSS 2.5) and 15 age-matched healthy controls.
Measured plasma oxidative stress markers (thiobarbituric acid reactive substances [TBARS], protein carbonyl [PCO], and total antioxidant capacity [TAC]) along with inflammatory markers (neutrophil/lymphocyte ratio [NLR] and erythrocyte sedimentation rate [ESR]).
Neutrophil/lymphocyte ratio (NLR) reliably identified the pro-inflammatory state characteristic of relapsing-remitting multiple sclerosis.
Elevated NLR was associated with reduced total antioxidant capacity (TAC), demonstrating linked oxidative stress and inflammation during early neuronal damage.

Cite This Study

Pădureanu et al. (2019) studied this question.

synapsesocial.com/papers/6a81acd4ffaafd634258c2da https://doi.org/10.3390/jcm8111815

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Implication

Case-control study reveals elevated neutrophil-lymphocyte ratio correlates with decreased antioxidant capacity in multiple sclerosis, suggesting oxidative stress promotes early neuronal damage.

Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis

Discussion

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Implication

Key Points

Cite This Study

Oxidative Stress and Inflammation Interdependence in Multiple Sclerosis

Discussion

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Implication

Key Points

Cite This Study

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