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November 2, 2004Clinical Endocrinology

Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome

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Why the study?

Is adiponectin independently associated with insulin sensitivity in women with polycystic ovary syndrome?

Population

62 women with polycystic ovary syndrome (PCOS) and 35 healthy female controls

Comparison

Metformin treatment for 6 months vs Healthy female controls

Design

Cross-sectional

Follow-up

6 months (for metformin subset)

Authors

JSJoachim SprangerUniversity of Wisconsin–MadisonMMMatthias MöhligUniversity of the WitwatersrandUWUta WegewitzFederal Institute for Occupational Safety and Health

Discussion

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Implication

Adiponectin may mark partial insulin resistance in PCOS but is unaffected by metformin; leaves open any therapeutic targeting.

Structured PICO

Is adiponectin independently associated with insulin sensitivity in women with polycystic ovary syndrome?

P
Population
62 women with polycystic ovary syndrome (PCOS) and 35 healthy female controls
I
Intervention
Metformin treatment for 6 months (in a subset of 9 insulin-resistant PCOS women)
C
Comparator
Healthy female controls (for the main observational analysis)
O
Outcome
Determinants of circulating adiponectin levels and its correlation with insulin resistancesurrogate

Adiponectin is independently associated with insulin resistance in PCOS women, independent of adiposity, but is not directly altered by PCOS itself or metformin therapy.

Cite This Study

Spranger et al. (2004) studied this question.

synapsesocial.com/papers/6a81ad8f2ac899ae0206d5bbhttps://doi.org/10.1111/j.1365-2265.2004.02159.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia2001 · 3,447 citations
  2. 2Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation2002 · 1,216 citations
  3. 3Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease1997 · 604 citations
  4. 4C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus2001 · 4,474 citations
  5. 5Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*1997 · 2,468 citations