April 25, 2014Circulation Arrhythmia and ElectrophysiologyOpen Access

Concomitant presence of ECG-LVH and prolonged-QT was associated with a higher risk of all-cause mortality (HR 1.63; 95% CI 1.12-2.36) compared to the absence of both conditions.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: General population (n=7506). Intervention: Concomitant ECG-LVH and prolonged-QTa vs. Group without ECG-LVH or prolonged-QTa. Primary outcome: All-cause mortality (HR 1.63, 95% CI 1.12-2.36).

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Why the study?

Does the concomitant presence of ECG-LVH and prolonged-QT increase the risk of all-cause mortality in the general population compared to either predictor alone or neither?

Population

7,506 participants from the US Third National Health and Nutrition Examination Survey, mean age 59.4±13.3…

Comparison

Presence of concomitant electrocardiographic… vs Absence of ECG-LVH or prolonged-QTa, or isolated…

Design

Cohort

Key result

Concomitant presence of ECG-LVH and prolonged-QT was associated with a higher risk of all-cause mortality (HR 1.63; 95% CI 1.12-2.36) compared to the absence of both conditions.

Authors

ESElsayed Z. Soliman ASAmit Shah ABAndrew Boerkircher

Discussion

Member takes

Overview

May aid combined ECG risk stratification in observational cohorts; leaves open whether it improves outcomes over standard care.

Study Design

Type

Cohort (n=7,506)

Multicenter

Yes

Structured PICO

Does the concomitant presence of ECG-LVH and prolonged-QT increase the risk of all-cause mortality in the general population compared to either predictor alone or neither?

Population

7,506 participants from the US general population (mean age 59.4 years, 53% female) evaluated for the mortality risk associated with ECG-LVH and prolonged-QT.

Exposure

Presence of concomitant electrocardiographic left ventricular hypertrophy (ECG-LVH) and prolonged heart-rate-adjusted QT (prolonged-QTa)

Comparator

Absence of ECG-LVH or prolonged-QTa, or isolated presence of either

Outcome

All-cause mortalityhard clinical

Main Result

Hazard Ratio: 1.63 (95% CI 1.12–2.36)

Concomitant presence of prolonged-QT and ECG-LVH carries a higher risk of all-cause mortality than either predictor alone, indicating both are independent markers of poor prognosis.

Cite This Study

Soliman et al. (2014) conducted a cohort in General population (n=7,506). Concomitant ECG-LVH and prolonged-QTa vs. Group without ECG-LVH or prolonged-QTa was evaluated on All-cause mortality (HR 1.63, 95% CI 1.12-2.36). Concomitant presence of ECG-LVH and prolonged-QT was associated with a higher risk of all-cause mortality (HR 1.63; 95% CI 1.12-2.36) compared to the absence of both conditions.

synapsesocial.com/papers/6a81ae1c5fe02a08f3d8263e https://doi.org/10.1161/circep.113.001396

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April 25, 2014Circulation Arrhythmia and ElectrophysiologyOpen Access

Concomitant presence of ECG-LVH and prolonged-QT was associated with a higher risk of all-cause mortality (HR 1.63; 95% CI 1.12-2.36) compared to the absence of both conditions.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the concomitant presence of ECG-LVH and prolonged-QT increase the risk of all-cause mortality in the general population compared to either predictor alone or neither?

Population

7,506 participants from the US Third National Health and Nutrition Examination Survey, mean age 59.4±13.3…

Comparison

Presence of concomitant electrocardiographic… vs Absence of ECG-LVH or prolonged-QTa, or isolated…

Design

Cohort

Key result

Concomitant presence of ECG-LVH and prolonged-QT was associated with a higher risk of all-cause mortality (HR 1.63; 95% CI 1.12-2.36) compared to the absence of both conditions.

Authors

ESElsayed Z. Soliman ASAmit Shah ABAndrew Boerkircher

Discussion

Member takes

Overview

May aid combined ECG risk stratification in observational cohorts; leaves open whether it improves outcomes over standard care.

Study Design

Type

Cohort (n=7,506)

Multicenter

Yes

Structured PICO

Does the concomitant presence of ECG-LVH and prolonged-QT increase the risk of all-cause mortality in the general population compared to either predictor alone or neither?

Population

7,506 participants from the US general population (mean age 59.4 years, 53% female) evaluated for the mortality risk associated with ECG-LVH and prolonged-QT.

Exposure

Presence of concomitant electrocardiographic left ventricular hypertrophy (ECG-LVH) and prolonged heart-rate-adjusted QT (prolonged-QTa)

Comparator

Absence of ECG-LVH or prolonged-QTa, or isolated presence of either

Outcome

All-cause mortalityhard clinical

Main Result

Hazard Ratio: 1.63 (95% CI 1.12–2.36)

Concomitant presence of prolonged-QT and ECG-LVH carries a higher risk of all-cause mortality than either predictor alone, indicating both are independent markers of poor prognosis.

Cite This Study

synapsesocial.com/papers/6a81ae1c5fe02a08f3d8263e https://doi.org/10.1161/circep.113.001396

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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