This preclinical study elucidates the distinct receptor-mediated pathways controlling blood flow and secretion in the rat submaxillary gland during autonomic nerve stimulation.
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Delineates receptor-specific autonomic control of submaxillary blood flow in rats; leaves open relevance to human salivary physiology and disease.
Blood flow and secretion from the submaxillary gland of the rat was recorded. Stimulation of the chordalingual nerve evoked vasodilatation which was little, it at all, decreased after administration of atropine. The secretion evoked on parasympathetic nerve stimulation was greatly reduced but not totally abolished by parasympatholytic agents. Stimulation of the cervical sympathetic trunk evoked secretion, which was mediated both via alpha and beta-adrenoceptors and vasoconstriction which was abolished by dihydroergotamine, and thus seemed to be mediated via alpha-adrenergic receptors. After alpha-adrenoceptor blockade vasodilatation was seen on sympathetic nerve stimulation. This was abolished by the beta-adrenoceptor blocking agent propranolol.
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Anders Thulin (1976) studied this question.
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