Key result
Chemotherapy and hormone replacement therapy for a brain germinoma and resulting panhypopituitarism shortened the QTc interval from 519 to 418 ms and eliminated syncopal episodes.
Case Report (n=1)
No
Brain tumors can cause QT prolongation and torsades de pointes through panhypopituitarism, highlighting the importance of checking QTc intervals in patients with transient loss of consciousness.
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Supports QTc assessment in brain tumor patients with syncope; leaves open confirmation via prospective studies.
We herein report the case of a 20-year-old man with a history of epilepsy who presented with frequent transient loss of consciousness (T-LOC) and polymorphic ventricular tachycardia (VT) with QT interval prolongation. Blood investigations revealed panhypopituitarism. Following a biopsy, he was diagnosed with brain germinoma. During the biopsy, he had an episode of polymorphous VT with QT prolongation. There was no recurrence of T-LOC following chemotherapy and hormone replacement therapy. This case indicates the importance of checking the QT interval in patients with T-LOC, including those with seizures and brain tumors, to ensure appropriate treatment.
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Nakayama et al. (2021) conducted a case report in Polymorphic Ventricular Tachycardia with QT Interval Prolongation (n=1). Chemotherapy and hormone replacement therapy was evaluated on QTc interval shortening and resolution of syncope. Chemotherapy and hormone replacement therapy for a brain germinoma and resulting panhypopituitarism shortened the QTc interval from 519 to 418 ms and eliminated syncopal episodes.
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