The determination of partition coefficients of organic compounds in technical products and waste waters for the estimation of their bioaccumulation potential using reversed phase thin layer chromatography

Reversed phase thin layer chromatography (RPTLC) has been investigated for the estimation of octanol/water partition coefficients (P), an important parameter for the prediction of the environmental behaviour of organic chemicals. A strong correlation between P derived from the traditional octanol/water system and RPTLC has been established over five orders of magnitude. RPTLC data are likewise correlated to results obtained by high performance chromatography (HPLC). Due to the low costs, simplicity and separation power RPTLC is especially suited for the investigation and screening of mixtures of compounds before more complicated tests are involved. Results from a round robin test on the determination of partition coefficients by HPLC, RPTLC and the batch method indicate the simplicity and accuracy of the RPTLC technique. Applications of the RPTLC‐technique on technical products and industrial waste waters are described.