What question did this study set out to answer?

To determine whether tumor necrosis factor (TNF) inhibitors attenuate anorexia and downregulate ubiquitin-proteasome pathway gene expression during monocrotaline-induced cardiac cachexia.

September 19, 2008Journal of Applied Physiology

Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia

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Authors

BSBrian T. SteffenUniversity of Minnesota SLSimon J. LeesNOSM University FBFrank W. BoothUniversity of Missouri

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Implication

Animal study demonstrates that anti-TNF therapies attenuate skeletal muscle wasting and anorexia in rats with cardiac cachexia, highlighting targeted cytokine inhibition to preserve muscle mass.

Key Points

To determine whether tumor necrosis factor (TNF) inhibitors attenuate anorexia and downregulate ubiquitin-proteasome pathway gene expression during monocrotaline-induced cardiac cachexia.
Cardiac cachexia was induced in Sprague-Dawley rats using monocrotaline.
At the first sign of cachexia, rats received either soluble TNF receptor-1 or pentoxifylline to inhibit TNF signaling.
Skeletal muscle tissues were excised after anesthesia to measure ubiquitin-proteasome pathway transcripts and protein levels via Western blotting.
Both soluble TNF receptor-1 and pentoxifylline significantly attenuated total body and skeletal muscle mass loss while reducing the expression of key ubiquitin-proteasome pathway transcripts.
Soluble TNF receptor-1 preserved muscle mass partly by reversing cachexia-associated anorexia, whereas pentoxifylline produced anti-wasting effects independently of food consumption.

Cite This Study

Steffen et al. (2008) studied this question.

synapsesocial.com/papers/6a81b414ac3bbfe76d60f4fa https://doi.org/10.1152/japplphysiol.90884.2008

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Implication

Animal study demonstrates that anti-TNF therapies attenuate skeletal muscle wasting and anorexia in rats with cardiac cachexia, highlighting targeted cytokine inhibition to preserve muscle mass.

Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia

Discussion

Member takes

Implication

Key Points

Cite This Study

Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia

Discussion

Member takes

Implication

Key Points

Cite This Study

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